Creating a keynote input to the UN Rio+20 process, the United Nation‘s Chief Scientist, Prof. Joseph Alcamo, established a foresight process to identify the top emerging issues the world needs to focus on. Co-designed and facilitated by Prospex, this process engaged over 400 scientists from around the world. In several workshops and online activities, the convened scientific community went through identifying issues and distilling from these an agreed set of 21 ranked issues: 21 issues for the 21st century. The sophisticated process produced deep insights in the environmental challenges to come. The scientists‘ message met lots of political and media attention worldwide, putting forward a call for nothing less but an overhaul on how the planet is being managed.